تفاعل #8927

معادلة التفاعل

benzyl 3-chlorosulfonyl-2(R)-methylpropionate

dimethylamine

→

benzyl 3-[(dimethylamino)sulfonyl]-2(R)-methylpropionate

المذيبات

CH2Cl2

ظروف التفاعل

المعالجة

1. 1
   أخرىA 100 mL round bottomed flask equipped with magnetic stir bar
2. 2
   تركيزAfter 30 minutes the reaction was concentrated in vacuo
3. 3
   أخرىThe organic phase was dried
4. 4
   تركيزconcentrated in vacuo

الإجراء التجريبي

A 100 mL round bottomed flask equipped with magnetic stir bar was charged with 1.7 g benzyl 3-chlorosulfonyl-2(R)-methylpropionate from Example 3 in 25 mL CH2Cl2. The solution was cooled to −78° C. and 15 mL of anhydrous dimethylamine was slowly added. After 30 minutes the reaction was concentrated in vacuo and the residue was partioned between EA/H2O. The organic phase was dried, concentrated in vacuo to yield 1.4 g of benzyl 3-[(dimethylamino)sulfonyl]-2(R)-methylpropionate as a clear amber oil which was used directly in the next step.

المصدر