تفاعل #8925

معادلة التفاعل

benzyl 3-chlorosulfonyl-2(R)-methylpropionate

ammonia

→

benzyl 3-aminosulfonyl-2(R)-methylpropionate

المذيبات

CH2Cl2

ethyl acetate

ظروف التفاعل

المعالجة

1. 1
   أخرىA 100 mL round bottom flask equipped with magnetic stir bar
2. 2
   درجة الحرارةAfter 20 minutes the reaction was warmed to room temperature
3. 3
   تركيزconcentrated in vacuo
4. 4
   أخرىto afford a white solid
5. 5
   ترشيحfiltered
6. 6
   أخرىto remove inorganic salts
7. 7
   تركيزconcentrated in vacuo

الإجراء التجريبي

A 100 mL round bottom flask equipped with magnetic stir bar was charged with 1.22 g of benzyl 3-chlorosulfonyl-2(R)-methylpropionate in 15 mL CH2Cl2 and cooled to −78° C. To this solution was added to 10 mL of liquid ammonia at −78° C. After 20 minutes the reaction was warmed to room temperature, concentrated in vacuo to afford a white solid. The solid was slurried in ethyl acetate, filtered to remove inorganic salts and concentrated in vacuo to afford 1.08 g of benzyl 3-aminosulfonyl-2(R)-methylpropionate as a clear yellow oil. The crude product was used without further purification.

المصدر