تفاعل #8924

معادلة التفاعل

benzyl 3-[(4-methylpiperizin-1-yl)sulfonyl]-2(R)-methylpropionate

→

3-[(4-methylpiperizin-1-yl)sulfonyl]-2(R)-methylpropionic acid

المذيبات

MeOH

ظروف التفاعل

المعالجة

1. 1
   أخرىHydrogenation at 50 psi for 48 hours afforded
2. 2
   ترشيحafter filtration
3. 3
   تركيزthrough Celite and concentration in vacuo

الإجراء التجريبي

A 100 mL Fisher/Porter vessel was charged with benzyl 3-[(4-methylpiperizin-1-yl)sulfonyl]-2(R)-methylpropionate in 15 mL MeOH with a catalytic amount of 10% Pd—C. Hydrogenation at 50 psi for 48 hours afforded, after filtration through Celite and concentration in vacuo to yield 3-[(4-methylpiperizin-1-yl)sulfonyl]-2(R)-methylpropionic acid as a hygroscopic foam suitable for use without further purification.

المصدر