تفاعل #8923

معادلة التفاعل

N-methyl-piperazine

NEt3

benzyl 3-chlorosulfonyl-2(R)-methylpropionate

→

benzyl 3-[(4-methylpiperizin-1-yl)sulfonyl]-2(R)-methylpropionate

المذيبات

CH2Cl2

CH2Cl2

ظروف التفاعل

المعالجة

1. 1
   أخرىA 100 mL round bottom flask equipped with magnetic stir bar
2. 2
   أخرىAfter 1 hour reaction
3. 3
   تركيزwas concentrated in vacuo
4. 4
   غسيلthe organic phase was washed with saturated aqueous bicarb
5. 5
   تجفيف, brine, dried
6. 6
   تركيزconcentrated in vacuo

الإجراء التجريبي

A 100 mL round bottom flask equipped with magnetic stir bar was charged with 0.42 mL (1.05 eq) N-methyl-piperazine, 1 mL NEt3 and 20 mL CH2Cl2. The solution was cooled to 0° C. and 1.0 g of benzyl 3-chlorosulfonyl-2(R)-methylpropionate from Example 3 in 5 mL CH2Cl2 was added. After 1 hour reaction was concentrated in vacuo. The residue was partioned between EA/H2O and the organic phase was washed with saturated aqueous bicarb., brine, dried, and concentrated in vacuo to yield benzyl 3-[(4-methylpiperizin-1-yl)sulfonyl]-2(R)-methylpropionate which was used without further purification.

المصدر