تفاعل #89110

معادلة التفاعل

hydrogen

tert-butyl (6-methylpyridin-2-yl)methylcarbamate

→

rac-tert-butyl (6-methylpiperidin-2-yl)methylcarbamate

المذيبات

MeOH

ظروف التفاعل

المعالجة

1. 1
   ترشيحThe reaction mixture was filtered through a pad of diatomaceous earth
2. 2
   تركيزthe filtrate was concentrated in vacuo

الإجراء التجريبي

Nishimura catalyst (0.53 g) was added to a solution of tert-butyl (6-methylpyridin-2-yl)methylcarbamate (4.4 g, 0.02 mmol) in MeOH (60 mL) in a Parr Shaker high pressure vessel which was installed on Parr Shaker. The vessel was shaken under constant 5 bar hydrogen pressure for 30 min. The reaction mixture was filtered through a pad of diatomaceous earth and the filtrate was concentrated in vacuo to give desired product rac-tert-butyl (6-methylpiperidin-2-yl)methylcarbamate which was used for next step without further purification. 1H NMR (CDCl3, 400 MHz) δ 3.20-3.17 (m, 1H), 3.01-2.96 (m, 1H), 2.72-2.64 (m, 2H), 1.82-1.77 (m, 1H), 1.63-1.54 (m, 2H), 1.49 (s, 9H), 1.39-1.35 (m, 2H), 1.12-0.99 (m, 5H).

المصدر