تفاعل #88896

معادلة التفاعل

2-fluoroadenosine

N-methylpyrazol-4-carboxamide

→

2-[4-[(methylamino)carbonyl]-1H-pyrazol-1-yl]adenosine

المذيبات

acetonitrile dimethylsulfoxide

ظروف التفاعل

المعالجة

1. 1
   أخرىpreparation of polymorph D by a relatively complicated procedure

الإجراء التجريبي

PCT application WO 2012/149196 describes preparation of polymorph D by a relatively complicated procedure. First, a “cross coupling” reaction of 2-fluoroadenosine with N-methylpyrazol-4-carboxamide in an acetonitrile/dimethylsulfoxide mixture provides crude 2-[4-[(methylamino)carbonyl]-1H-pyrazol-1-yl]adenosine, which is then purified by reverse-phase chromatography using a methanol/water mixture. After concentrating at 150° C. under reduced pressure, polymorph D is obtained as a white solid substance containing variable amounts of water.

المصدر