تفاعل #88663

معادلة التفاعل

2-bromofuro[3,2-c]pyridin-4(5H)-one

lithium 1-(5-chloropyridin-2-yl)-4-methyl-2,6,7-trioxa-1-borabicyclo[2.2.2]octan-1-uide

triphenylphosphine

→

title compound

المردود 29.9%

2-(5-Chloropyridin-2-yl)furo[3,2-c]pyridin-4(5H)-one

المردود 29.9%

المذيبات

DMA

ظروف التفاعل

المعالجة

1. 1
   أخرىThe reaction mixture was purified by silica gel column chromatography (NH, methanol/ethyl acetate)
2. 2
   غسيلthe obtained solid was washed with diisopropyl ether

الإجراء التجريبي

A mixture of 2-bromofuro[3,2-c]pyridin-4(5H)-one (200 mg), lithium 1-(5-chloropyridin-2-yl)-4-methyl-2,6,7-trioxa-1-borabicyclo[2.2.2]octan-1-uide (462 mg), palladium(II) acetate (21.0 mg), copper(I) iodide (178 mg), triphenylphosphine (49.0 mg) and DMA (1.0 mL) was heated at 250° C. for 30 min under microwave irradiation. The reaction mixture was purified by silica gel column chromatography (NH, methanol/ethyl acetate), and the obtained solid was washed with diisopropyl ether to give the title compound (69.0 mg) as a white solid.

المصدر