تفاعل #88662

معادلة التفاعل

3-(5-bromo-2-furyl)acryloyl azide

diphenyl ether

tributylamine

→

title compound

2-Bromofuro[3,2-c]pyridin-4(5H)-one

المذيبات

tert-butyl methyl ether

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةto cool to room temperature
2. 2
   ترشيحThe resulting solid was collected by filtration
3. 3
   أخرىThe obtained solid was purified by silica gel column chromatography (hexane
4. 4
   workup.ADDITIONTo the obtained fraction was added a saturated aqueous sodium hydrogen carbonate solution
5. 5
   استخلاصthe mixture was extracted with ethyl acetate
6. 6
   تجفيفThe extract was dried over anhydrous magnesium sulfate
7. 7
   تركيزconcentrated in vacuo
8. 8
   أخرىrecrystallized from ethyl acetate

الإجراء التجريبي

A mixture of 3-(5-bromo-2-furyl)acryloyl azide (20.7 g), diphenyl ether (200 mL) and tributylamine (16 mL) was stirred at 220-230° C. for 30 min under a nitrogen atmosphere. The reaction mixture was allowed to cool to room temperature, and tert-butyl methyl ether (200 mL) was added thereto. The resulting solid was collected by filtration. The obtained solid was purified by silica gel column chromatography (hexane, then ethyl acetate/THF), followed by HPLC (C18, mobile phase: water/acetonitrile (including 0.1% TFA)). To the obtained fraction was added a saturated aqueous sodium hydrogen carbonate solution, and the mixture was extracted with ethyl acetate. The extract was dried over anhydrous magnesium sulfate, concentrated in vacuo, and recrystallized from ethyl acetate to give the title compound (7.00 g) as a white solid.

المصدر