تفاعل #88661

معادلة التفاعل

sodium azide

3-(5-bromo-2-furyl)acrylic acid

triethylamine

ethyl chloroformate

→

title compound

المردود 44.7%

3-(5-Bromo-2-furyl)acryloyl azide

المردود 44.7%

المذيبات

acetonitrile

ظروف التفاعل

المعالجة

1. 1
   workup.STIRRINGthe mixture was stirred at room temperature for 5 hr
2. 2
   ترشيحThe reaction mixture was filtered
3. 3
   غسيلthe obtained solid was washed with water
4. 4
   أخرىThe solid was recrystallized from dichloromethane

الإجراء التجريبي

To a solution of 3-(5-bromo-2-furyl)acrylic acid (41.5 g) in acetonitrile (200 mL) were added triethylamine (23.0 g) and ethyl chloroformate (26.1 g). The mixture was stirred at room temperature for 30 min. To the obtained mixture was added a saturated aqueous solution of sodium azide (18.7 g) at 0° C. and the mixture was stirred at room temperature for 5 hr. The reaction mixture was filtered, and the obtained solid was washed with water. The solid was recrystallized from dichloromethane to give the title compound (20.7 g) as white solid.

المصدر