تفاعل #8848

معادلة التفاعل

ammonium chloride

tert-Butyl 1-oxo-8-azaspiro[4.5]decane-8-carboxylate

lithium diisopropylamide mono(tetrahydrofuran)

acetaldehyde

→

clear oil

tert-Butyl 2-(1-hydroxyeth-1-yl)-1-oxo-8-azaspiro[4.5]decane 8-carboxylate

المذيبات

diethyl ether

ظروف التفاعل

المعالجة

1. 1
   أخرىby evaporating with toluene (5 mL) three times in vacuo
2. 2
   workup.DISSOLUTIONdissolved in tetrahydrofuran (50 mL)
3. 3
   workup.WAITAfter 10 min
4. 4
   استخلاصextracted three times with diethyl ether
5. 5
   غسيلwashed with brine
6. 6
   تجفيفdried over sodium sulfate
7. 7
   ترشيحfiltered
8. 8
   تركيزconcentrated

الإجراء التجريبي

tert-Butyl 1-oxo-8-azaspiro[4.5]decane-8-carboxylate from Procedure 1, Step G (1.2 g, 4.70 mmol) was dried by evaporating with toluene (5 mL) three times in vacuo, dissolved in tetrahydrofuran (50 mL), and cooled to −78° C. To this solution was added lithium diisopropylamide mono(tetrahydrofuran) (6.3 mL, 9.4 mmol, 1.5 M in cyclohexane). The reaction mixture was stirred for 35 min at −78° C. before adding acetaldehyde (0.527 mL, 9.4 mmol). After 10 min, the reaction mixture was diluted with diethyl ether, poured into saturated ammonium chloride, and extracted three times with diethyl ether. The organic layers were combined, washed with brine, dried over sodium sulfate, filtered, and concentrated to afford 6.7 g of a clear oil. The residue was purified by flash chromatography eluting with 20–40% ethyl acetate/hexanes to give the title compound (0.620 g).

المصدر