تفاعل #88400

معادلة التفاعل

sodium hydroxide

methyl 4-(4,5-dimethylthiazol-2-yl)-1-methyl-1H-pyrazole-5-carboxylate

→

title compound

sodium 4-(4,5-dimethylthiazol-2-yl)-1-methyl-1H-pyrazole-5-carboxylate

المذيبات

methanol

ظروف التفاعل

المعالجة

1. 1
   أخرىobtained in (Example 2.2) <Step 1>
2. 2
   درجة الحرارةthe obtained mixture was then heated
3. 3
   درجة الحرارةto reflux for 15 minutes
4. 4
   workup.DISTILLATIONThereafter, the solvent was distilled away under reduced pressure

الإجراء التجريبي

An aqueous solution (1 ml) of sodium hydroxide (9.6 mg) was added to a methanol (1 ml) solution of the methyl 4-(4,5-dimethylthiazol-2-yl)-1-methyl-1H-pyrazole-5-carboxylate (30 mg) obtained in (Example 2.2) <Step 1>, and the obtained mixture was then heated to reflux for 15 minutes. Thereafter, the solvent was distilled away under reduced pressure, and the residue was then subjected to azeotropy with toluene, so as to obtain a crude product of the title compound.

المصدر