تفاعل #8839

معادلة التفاعل

BOC-isonipecotic acid

trimethylsilyldiazomethane

→

title compound

المردود 96.6%

Methyl 1-(tert-butoxycarbonyl)piperidine-4-carboxylate

المردود 96.6%

المذيبات

dichloromethane methanol

ظروف التفاعل

المعالجة

1. 1
   تركيزThe reaction mixture was then concentrated

الإجراء التجريبي

To a solution of BOC-isonipecotic acid (45.0 g, 0.20 mol) dissolved in a 3:1 solution of dichloromethane/methanol (1200 mL) at 0° C. was added a solution of trimethylsilyldiazomethane (147 mL, 0.29 mol, 2.0M in hexane) over 30 min via an addition funnel. The reaction mixture was then concentrated to afford the title compound (47 g) as a light yellow oil. This was used directly in the next step without further purification.

المصدر