تفاعل #88232

معادلة التفاعل

dimethyl 4-chloropyridine-3,5-dicarboxylate

formimidamide acetate

NaH

→

title compound

المردود 56.1%

Methyl 4-hydroxypyrido[4,3-d]pyrimidine-8-carboxylate

المردود 56.1%

المذيبات

dioxane

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةThe resulting mixture was refluxed for 48 hours
2. 2
   ترشيحThe precipitate was filtered
3. 3
   غسيلwashed with EA

الإجراء التجريبي

To the mixture of dimethyl 4-chloropyridine-3,5-dicarboxylate (0.6 g, 2.6 mmol) and formimidamide acetate (0.82 g, 7.8 mmol) in dioxane (20 mL) was added NaH (0.31 g, 7.8 mmol). The resulting mixture was refluxed for 48 hours, cooled to RT. The precipitate was filtered, and washed with EA to afford the title compound as grey solid (yield 56.1%).

المصدر