تفاعل #88226

معادلة التفاعل

DCM

NaH

3-fluoro-4-[(3-methylbenzimidazol-5-yl)amino]benzonitrile

MeI

→

Compound C

3-fluoro-4-[methyl-(3-methylbenzimidazol-5-yl)amino]benzonitrile

المذيبات

THF

ظروف التفاعل

المعالجة

1. 1
   workup.STIRRINGthe mixture was stirred at room temperature during 3 h
2. 2
   غسيلwashed (H2O)
3. 3
   تركيزconcentrated
4. 4
   أخرىThe residue was purified by prep HPLC

الإجراء التجريبي

NaH (7.14 mmol) was added to a solution of 3-fluoro-4-[(3-methylbenzimidazol-5-yl)amino]benzonitrile (2.38 mmol) in THF (10 mL) at 0° C. The mixture was stirred for 30 min. MeI (4.76 mmol) was added and the mixture was stirred at room temperature during 3 h. The mixture was diluted (DCM), washed (H2O) and concentrated. The residue was purified by prep HPLC to yield the desired product (Compound C).

المصدر