تفاعل #88219

معادلة التفاعل

4-amino-3-fluorobenzonitrile

NCS

→

desired product

4-amino-3-chloro-5-fluoro-benzonitrile

المذيبات

AcOH

ظروف التفاعل

المعالجة

1. 1
   تركيزThe mixture was concentrated
2. 2
   workup.ADDITIONH2O was added to the residue
3. 3
   ترشيحthe solid product was filtered off
4. 4
   غسيلwashed (sat. NaHCO3 and H2O)
5. 5
   workup.ADDITIONwas added
6. 6
   أخرىremoved under reduced pressure

الإجراء التجريبي

A mixture of 4-amino-3-fluorobenzonitrile (184 mmol) and NCS (276 mmol) in AcOH (300 mL) was stirred at 70° C. for approximately 16 h. The mixture was concentrated. H2O was added to the residue and the solid product was filtered off and washed (sat. NaHCO3 and H2O). To eliminate H2O, THF was added and removed under reduced pressure to yield the desired product.

المصدر