تفاعل #8817

معادلة التفاعل

2-chloro-6,7-dimethoxy-3H-quinazolin-4-one

1-benzyl-1,4,6,7-tetrahydro-imidazo[4,5-c]pyridine dihydrochloride

diisopropylethylamine

→

2-(1-benzyl-1,4,6,7-tetrahydro-imidazo[4,5-c]pyridin-5-yl)-6,7-dimethoxy-3H-quinazolin-4-one

المردود 29.9%

المذيبات

2-methoxyethanol

water

ظروف التفاعل

المعالجة

1. 1
   تركيزThe reaction mixture was concentrated in vacuo
2. 2
   أخرىto give an oil residue, which
3. 3
   أخرىThe white precipitate that formed
4. 4
   ترشيحwas collected by filtration

الإجراء التجريبي

A mixture of 2-chloro-6,7-dimethoxy-3H-quinazolin-4-one 1 (wherein R is methyl and Z is —C(O)—, 296 mg, 1.24 mmol), 1-benzyl-1,4,6,7-tetrahydro-imidazo[4,5-c]pyridine dihydrochloride 15a (440 mg, 1.54 mmol)) and diisopropylethylamine (1.2 g, 9.26 mmol) in 2-methoxyethanol (10 mL) was stirred at 120° C. for 6 hours. The reaction mixture was concentrated in vacuo to give an oil residue, which was diluted with water. The white precipitate that formed was collected by filtration to give 155 mg of 2-(1-benzyl-1,4,6,7-tetrahydro-imidazo[4,5-c]pyridin-5-yl)-6,7-dimethoxy-3H-quinazolin-4-one 501, [M+H]+=418.

المصدر