تفاعل #88014

معادلة التفاعل

methyl 3-(methylsulfonamido)thiophene-2-carboxylate

NaOH

HCl

→

3-(methylsulfonamido)thiophene-2-carboxylic acid

المردود 99.3%

المذيبات

THF

ظروف التفاعل

المعالجة

1. 1
   استخلاصthe mixture was extracted with EtOAc (×3)
2. 2
   تجفيفThe combined organic layers were dried over Na2SO4
3. 3
   أخرىevaporated to dryness

الإجراء التجريبي

A mixture of methyl 3-(methylsulfonamido)thiophene-2-carboxylate (Int. 37) (193 mg, 0.820 mmol) in aqueous 2M NaOH (4.10 ml, 8.20 mmol) and THF (4.1 ml) was heated under microwaves irradiation at 80° C. for 30 minutes. 2N HCl was added (pH=2) and the mixture was extracted with EtOAc (×3). The combined organic layers were dried over Na2SO4 and evaporated to dryness affording 3-(methylsulfonamido)thiophene-2-carboxylic acid (Int. 38) (180 mg, 0.814 mmol, MS/ESI+221.8 [MH]+).

المصدر