تفاعل #8769

معادلة التفاعل

3-[3-(2-bromo-ethoxy)-phenyl]-thieno[2,3-d]isoxazole

potassium carbonate

2-fluorobenzylamine

→

title compound

المردود 83.4%

(2-fluoro-benzyl)-[2-(3-thieno[2,3-d]isoxazol-3-yl-phenoxy)-ethyl]-amine

المردود 83.4%

المذيبات

acetonitrile

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةCool the reaction mixture
2. 2
   ترشيحfilter through a Waters Sep-Pak 1 g silica cartridge (ethyl acetate)
3. 3
   تركيزCombine the appropriate fractions and concentrate
4. 4
   أخرىto give a residue
5. 5
   أخرىPurify the residue by column (10 g silica) chromatography

الإجراء التجريبي

Mix 3-[3-(2-bromo-ethoxy)-phenyl]-thieno[2,3-d]isoxazole (0.40 g, 1.23 mmol), potassium carbonate (0.341 g, 2.47 mmol), 2-fluorobenzylamine (0.626 g, 5.0 mmol) and acetonitrile (5.0 mL) and heat at 80° C., overnight. Cool the reaction mixture and filter through a Waters Sep-Pak 1 g silica cartridge (ethyl acetate). Combine the appropriate fractions and concentrate to give a residue. Purify the residue by column (10 g silica) chromatography using a solvent gradient of 40% ethyl acetate in heptane to 100% ethyl acetate to obtain the title compound (0.378 g, 83% Yield). Purity by LC/MS (APCI)=99%, [M+H]+=369.

المصدر