تفاعل #87650

معادلة التفاعل

5-((2,2,2-trifluoroacetamido)methyl)-2-chloro-4-methoxybenzoyl isocyanate

tert-butyl 2-(4-(trifluoromethyl)phenyl)hydrazinecarboxylate

trifluoro acetic acid

→

desired product

المردود 24.5%

N-(4-chloro-5-(1-(4-(trifluoromethyl)phenyl)-4,5-dihydro-5-oxo-1H-1,2,4-triazol-3-yl)-2-methoxybenzyl)-2,2,2-trifluoroacetamide

المردود 24.5%

المذيبات

DCM

ظروف التفاعل

المعالجة

1. 1
   أخرىThe title compound was prepared

الإجراء التجريبي

The title compound was prepared according to the procedure described in Example-83 by using 5-((2,2,2-trifluoroacetamido)methyl)-2-chloro-4-methoxybenzoyl isocyanate (0.500 g), tert-butyl 2-(4-(trifluoromethyl)phenyl)hydrazinecarboxylate (Intermediate-53, 0.450 g), DCM (20 mL), and trifluoro acetic acid (5.0 mL) to afford 0.180 g of the desired product.

المصدر