تفاعل #87568

معادلة التفاعل

N-(4-chloro-3-nitrobenzyl)-2,2,2-trifluoroacetamide

HCl

→

desired product

(4-chloro-3-nitrophenyl)methanamine hydrochloride

المذيبات

methanol

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةThe reaction mass was refluxed for 18 h
2. 2
   أخرىExcess solvent was removed under vacuum

الإجراء التجريبي

To a solution of N-(4-chloro-3-nitrobenzyl)-2,2,2-trifluoroacetamide (0.800 g) in methanol (20 mL) was added conc. HCl (2.0 ml). The reaction mass was refluxed for 18 h. Excess solvent was removed under vacuum to afford 0.700 g of desired product. 1H NMR (300 MHz, DMSO d6): δ 7.18 (s, 1H), 7.35 (s, 1H), 7.52 (s, 1H), 7.86 (s, 2H); 8.28 (s, 1H), 8.72 (br s, 2H).

المصدر