تفاعل #87292

معادلة التفاعل

3-Bromo-2,3-dihydro-1H-inden-1-one

cyclohexylamine

cyclohexylamine

→

title compound

المردود 84.0%

3-(Cyclohexylamino)-2,3-dihydro-1H-inden-1-one

المردود 84.0%

المذيبات

benzene

ظروف التفاعل

المعالجة

1. 1
   أخرى(˜15 min)
2. 2
   أخرىHBr was removed by filtration

الإجراء التجريبي

3-Bromo-2,3-dihydro-1H-inden-1-one (100 mg, 475 μmol) and cyclohexylamine (94 mg, 951 μmol) were dissolved in 2 mL of dry benzene and stirred under N2 until precipitation ceased (˜15 min) The cyclohexylamine.HBr was removed by filtration. The filtrate was applied to a flash SiO2 column that was developed with 8:1 hexanes-EtOAc to give the title compound as a clear oil (91 mg, 84% yield).

المصدر