تفاعل #871

معادلة التفاعل

HCl dioxane

N-t-butoxycarbonyl-(R)-α-ethoxymethylbenzylamine

→

(R)-α-ethoxymethylbenzylamine hydrochloride

ظروف التفاعل

المعالجة

1. 1
   تركيزThe reaction mixture was concentrated under reduced pressure, 30 ml of ether
2. 2
   workup.ADDITIONwas added to the residue
3. 3
   تركيزthis was further concentrated

الإجراء التجريبي

12.5 ml of 4N-HCl/dioxane solution were added to 0.66 g (2.5 mmols) of N-t-butoxycarbonyl-(R)-α-ethoxymethylbenzylamine, and the mixture was stirred at room temperature for one hour. The reaction mixture was concentrated under reduced pressure, 30 ml of ether was added to the residue, and this was further concentrated to obtain (R)-α-ethoxymethylbenzylamine hydrochloride at a quantitative yield.

المصدر