تفاعل #8708

معادلة التفاعل

4,6-dichloro-5-(4-chlorophenyl)pyrimidine

2-thiophen-2-yl-ethanesulfonic acid amide potassium salt

Hunig's base

→

2-thiophen-2-yl-ethanesulfonic acid [6-chloro-5-(4-chloro-phenyl)-pyrimidin-4-yl]-amide

المردود 68.7%

المذيبات

DMSO

water

ظروف التفاعل

المعالجة

1. 1
   استخلاصextracted twice with diethyl ether
2. 2
   أخرىThe precipitate was collected
3. 3
   غسيلwashed with water and diethyl ether
4. 4
   أخرىdried

الإجراء التجريبي

A solution of 4,6-dichloro-5-(4-chlorophenyl)pyrimidine (848 mg), 2-thiophen-2-yl-ethanesulfonic acid amide potassium salt (1.5 g, Referential Example 14) and Hunig's base (1 ml) in DMSO (20 ml) was stirred at rt for 24 h before it was diluted with water (200 ml) and extracted twice with diethyl ether. The aqueous layer was acidified with acetic acid. The precipitate was collected, washed with water and diethyl ether and dried to give 2-thiophen-2-yl-ethanesulfonic acid [6-chloro-5-(4-chloro-phenyl)-pyrimidin-4-yl]-amide (930 mg) as a beige powder. LC-MS: tR=5.01 min, [M+1]+=413.49, [M−1]−=411.93.

المصدر