تفاعل #87006

معادلة التفاعل

N,N-diisopropylethylamine

2-(5-chloro-1H-indol-3-yl)ethanamine hydrochloride

1-(3,5-difluorophenyl)-2-oxopyrrolidine-3-carboxylic acid

HATU

→

N-(2-(5-chloro-1H-indol-3-yl)ethyl)-1-(3,5-difluorophenyl)-2-oxopyrrolidine-3-carboxamide

المردود 26.0%

المذيبات

DMF

ظروف التفاعل

المعالجة

1. 1
   أخرىThis compound was prepared
2. 2
   أخرىThe crude material was purified by flash chromatography on silica gel (eluent: 2 to 20% of ethyl acetate in dichloromethane)

الإجراء التجريبي

This compound was prepared according to method A with 2-(5-chloro-1H-indol-3-yl)ethanamine hydrochloride (0.100 g; 0.424 mmol), 1-(3,5-difluorophenyl)-2-oxopyrrolidine-3-carboxylic acid (0.110 g; 0.445 mmol), HATU (0.166 g; 0.437 mmol) and N,N-diisopropylethylamine (0.186 mL; 1.06 mmol) in DMF (5 mL). The crude material was purified by flash chromatography on silica gel (eluent: 2 to 20% of ethyl acetate in dichloromethane) to give 0.046 g (26%) of N-(2-(5-chloro-1H-indol-3-yl)ethyl)-1-(3,5-difluorophenyl)-2-oxopyrrolidine-3-carboxamide as a white solid.

المصدر