تفاعل #86989

معادلة التفاعل

N,N diisopropylethylamine

2-(5-chloro-1H-indol-3-yl)ethanamine hydrochloride

2-oxo-1-(4-(trifluoromethoxy)phenyl)pyrrolidine-3-carboxylic acid

PyBOP

→

N-(2-(5-chloro-1H-indol-3-yl)ethyl)-2-oxo-1-(4-(trifluoromethoxy)phenyl)pyrrolidine-3-carboxamide

المردود 37.2%

المذيبات

DMF

ظروف التفاعل

المعالجة

1. 1
   أخرىThis compound was prepared
2. 2
   أخرىThe crude mixture was purified by flash chromatography on silica (eluent 20 to 100% ethyl acetate in heptane)

الإجراء التجريبي

This compound was prepared according to method E with 2-(5-chloro-1H-indol-3-yl)ethanamine hydrochloride (0.100 g; 0.433 mmol), 2-oxo-1-(4-(trifluoromethoxy)phenyl)pyrrolidine-3-carboxylic acid (0.125; 0.433 mmol), PyBOP (0.225 g; 0.433 mmol), N,N diisopropylethylamine (0.186 mL; 1.08 mmol) in DMF (3 mL). The crude mixture was purified by flash chromatography on silica (eluent 20 to 100% ethyl acetate in heptane) to yield 0.075 g (37%) of N-(2-(5-chloro-1H-indol-3-yl)ethyl)-2-oxo-1-(4-(trifluoromethoxy)phenyl)pyrrolidine-3-carboxamide as a solid.

المصدر