تفاعل #8698

معادلة التفاعل

4,6-dichloro-5-(2-methoxyphenoxy)-2-(4-pyridyl)-pyrimidine

2-phenyl-ethanesulfonic acid amide potassium salt

→

2-phenyl-ethanesulfonic acid [6-chloro-5-(2-methoxy-phenoxy)-2-pyridin-4-yl-pyrimidin-4-yl]-amide

المردود 78.1%

المذيبات

DMF

ظروف التفاعل

المعالجة

1. 1
   أخرىBulk of the solvent was evaporated before it
2. 2
   workup.ADDITIONwas diluted with diethyl ether (50 ml)
3. 3
   أخرىThe precipitate that formed
4. 4
   أخرىwas collected
5. 5
   غسيلwashed with diethyl ether (100 ml)
6. 6
   أخرىdried

الإجراء التجريبي

A solution of 4,6-dichloro-5-(2-methoxyphenoxy)-2-(4-pyridyl)-pyrimidine (2 g) and 2-phenyl-ethanesulfonic acid amide potassium salt (2.82 g, Referential Example 1e) in DMF (50 ml) was stirred at rt for 16 h. Bulk of the solvent was evaporated before it was diluted with diethyl ether (50 ml). The mixture was acidified with 10% aq. citric acid. The precipitate that formed was collected, washed with diethyl ether (100 ml) and dried to give 2-phenyl-ethanesulfonic acid [6-chloro-5-(2-methoxy-phenoxy)-2-pyridin-4-yl-pyrimidin-4-yl]-amide (2.23 g) as a beige powder. LC-MS: tR=4.93 min, [M+1]+=497.22, [M−1]−=494.96.

المصدر