تفاعل #8694

معادلة التفاعل

K3PO4

1-bromo-3,4-dimethyl-benzene

EA

→

2-(3,4-dimethyl-phenyl)-malonic acid dimethyl ester

المذيبات

THF

ظروف التفاعل

المعالجة

1. 1
   workup.ADDITIONwas added under argon
2. 2
   درجة الحرارةThe mixture was refluxed for 16 h
3. 3
   ترشيحfiltered
4. 4
   أخرىThe filtrate was evaporated
5. 5
   أخرىthe resulting brown oil was purified on silica gel eluting with heptane:EA 4:1 to 1:1

الإجراء التجريبي

(In analogy to a procedure given in J. Am. Chem. Soc. 122 (2000), 1360-1370.) To a suspension of Pd(OAc)2 (455 mg), 2-(di-tert.-butylphosphino)-biphenyl (1.21 g) and K3PO4 (39.6 g) in THF (200 ml) dimethylmalonate (12.85 g) and 1-bromo-3,4-dimethyl-benzene 15.0 g) was added under argon. The mixture was refluxed for 16 h, cooled to rt and diluted with EA (300 ml) and filtered. The filtrate was evaporated and the resulting brown oil was purified on silica gel eluting with heptane:EA 4:1 to 1:1 to give 2-(3,4-dimethyl-phenyl)-malonic acid dimethyl ester (16.2 g) as a colourless oil which slowly crystallises. 1H-NMR (300 MHz, CDCl3): 2.25(s, 3H), 2.26(s, 3H), 3.75(s, 6H), 4.59(s, 1H), 7.10–7.20(m, 3H).

المصدر