تفاعل #8688

معادلة التفاعل

2-phenylethanesulfonyl chloride

ammonia

HCl

→

2-phenyl-ethanesulfonic acid amide

المذيبات

THF

ظروف التفاعل

المعالجة

1. 1
   أخرىthe organic solvent was evaporated
2. 2
   workup.ADDITIONThe remaining suspension was diluted with water
3. 3
   استخلاصextracted four times with EA
4. 4
   أخرىevaporated

الإجراء التجريبي

A solution of 2-phenylethanesulfonyl chloride (40.94 g) in THF (250 ml) was cooled to −20° C. before it was treated with sat. aq. ammonia (50 ml). The brown suspension was stirred at rt for 16 h. The mixture was neutralised with aq. HCl and the organic solvent was evaporated. The remaining suspension was diluted with water and extracted four times with EA. The organic layers were combined and evaporated to give 2-phenyl-ethanesulfonic acid amide (33.06 g) as orange solid. 1H-NMR(300 MHz, CDCl3): 3.15–3.21(m, 2H), 3.38–3.45(m, 2H), 4.59(s br, 2H), 7.21–7.37(m, 5H).

المصدر