تفاعل #86672

معادلة التفاعل

(S)-2-Amino-6-hydroxy-hexanoic acid

MeOH

SOCl2

→

methyl ester

المردود 99.0%

(S)-2-Amino-6-hydroxy-hexanoic acid methyl ester

المردود 99.0%

ظروف التفاعل

المعالجة

1. 1
   أخرىwas removed in vacuo
2. 2
   أخرىThe crude solid was recrystallised from MeOH (3×100)

الإجراء التجريبي

(S)-2-Amino-6-hydroxy-hexanoic acid (Chemstep) (5.54 mmol, 1.37 g) was dissolved in 100 mL of MeOH and cooled at 0° C. SOCl2 (13.8 mmol, 1 mL, 2.5 eq) was added dropwise. The reaction mixture was stirred overnight at room temperature after which time the solvent was removed in vacuo. The crude solid was recrystallised from MeOH (3×100) to give the methyl ester 82 as an oil (5.52 mmol, 0.89 g, 99%).

المصدر