تفاعل #86668

معادلة التفاعل

Carboxylic acid

(S)-2-Benzyloxycarbonylamino-but-3-enoic acid methyl ester

thionyl chloride

→

(S)-2-Amino-but-3-enoic acid methyl ester hydrochloride

المذيبات

methanol

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةThis was cooled in ice
2. 2
   تركيزat rt for 18 h before being concentrated in vacuo
3. 3
   أخرىto afford a white solid, 0.388 g, (100%)

الإجراء التجريبي

Carboxylic acid 62 (0.350 g, 2.56 mmol) was suspended in methanol (10 mL). This was cooled in ice and 20% (v/v) thionyl chloride was added portionwise. The solution was stirred in ice for 1 h and then at rt for 18 h before being concentrated in vacuo to afford a white solid, 0.388 g, (100%).

المصدر