تفاعل #8650

ord-7699baaddd76414b851d402dc61a2e83

معادلة التفاعل

CCC(=O)N(c1ccccc1)C1CCN(CCc2ccccc2)CC1.O=C(O)CC(O)(CC(=O)O)C(=O)O
fentanyl citrate
COC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CC(=O)O
aspartame
OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO
mannitol
→
CCC(=O)N(c1ccccc1)C1CCN(CCc2ccccc2)CC1
Fentanyl

المتفاعلات

CCC(=O)N(c1ccccc1)C1CCN(CCc2ccccc2)CC1.O=C(O)CC(O)(CC(=O)O)C(=O)O
fentanyl citrate
COC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CC(=O)O
aspartame
OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO
mannitol

الكواشف

لا شيء

المذيبات

O
water
O
water

ظروف التفاعل

الظروف التفصيلية
See reaction.notes.procedure_details.

المعالجة

  1. 1
    workup.ADDITIONby mixing thoroughly in the bowl of a vacuum mixer
  2. 2
    درجة الحرارةThe mix was then heated to 40° C.±2° C.
  3. 3
    workup.DISSOLUTIONdissolution of the solids
  4. 4
    درجة الحرارةWhen cooled
  5. 5
    workup.STIRRINGThe mix was then homogenized
  6. 6
    workup.DISSOLUTIONdissolution of the solids
  7. 7
    workup.ADDITIONthe bulk mix
  8. 8
    workup.STIRRINGhomogenized
  9. 9
    workup.DISSOLUTIONdissolution

الإجراء التجريبي

Gelatin (765 g) and mannitol (540 g) were dispersed in a portion of purified water (16 kg) by mixing thoroughly in the bowl of a vacuum mixer. The mix was then heated to 40° C.±2° C. and homogenised for ten minutes to allow complete dissolution of the solids. The mix was cooled down to room temperature (20–24° C.). When cooled, the fentanyl citrate (22.68 g), the aspartame (90 g), and mint flavour (90 g) were added sequentially to the mix. The mix was then homogenized to ensure complete dissolution of the solids. The remaining water (492 g) was added to the mixer and the bulk mix homogenized to ensure dissolution was complete.

المصدر

DOI: 10.6084/m9.figshare.5104873.v1براءة الاختراع: US07090866B2uspto-grants-2006_08