تفاعل #86242

معادلة التفاعل

2-bromo-6-fluoropyridine

1,4-diazepan-6-ol

DIPEA

→

1-(6-Bromopyridin-2-yl)-1,4-diazepan-6-ol

المذيبات

EtOH

ظروف التفاعل

المعالجة

1. 1
   أخرىAfter completion of the reaction, it
2. 2
   تركيزwas concentrated under reduced pressure
3. 3
   أخرىThe crude material was used in the next step without further purification

الإجراء التجريبي

To a mixture of 2-bromo-6-fluoropyridine (845 mg, 4.83 mmol) and 1,4-diazepan-6-ol (560 mg, 4.83 mmol) in EtOH (20 mL) was added DIPEA (5 mL). The reaction mixture was heated at 100° C. for 15 hours, which was monitored by LCMS. After completion of the reaction, it was concentrated under reduced pressure. The crude material was used in the next step without further purification. MS (ESI) m/z: 272 [M+H]+.

المصدر