تفاعل #86099

معادلة التفاعل

1-(6-fluoropyridin-2-yl)-6-(5-(oxetan-3-yl)pyridin-3-yl)-1H-pyrazolo[4,3-c]pyridine

(S)-2-methylpiperazine

→

solid

المردود 24.0%

(S)-1-(6-(3-methylpiperazin-1-yl)pyridin-2-yl)-6-(5-(oxetan-3-yl)pyridin-3-yl)-1H-pyrazolo[4,3-c]pyridine

المردود 24.0%

ظروف التفاعل

الإجراء التجريبي

Following the procedures as described in EXAMPLE 8 and starting with 1-(6-fluoropyridin-2-yl)-6-(5-(oxetan-3-yl)pyridin-3-yl)-1H-pyrazolo[4,3-c]pyridine and (S)-2-methylpiperazine, 113 was obtained as an off-white solid (26.3 mg, 24%). 1H NMR (400 MHz, DMSO) δ 9.39-9.28 (m, 1H), 9.20-9.11 (d, J=2.1 Hz, 1H), 9.11-9.02 (s, 1H), 8.72-8.61 (m, 2H), 8.60-8.53 (t, J=2.1 Hz, 1H), 7.84-7.67 (t, J=8.1 Hz, 1H), 7.32-7.18 (d, J=7.7 Hz, 1H), 6.87-6.76 (d, J=8.5 Hz, 1H), 5.08-4.98 (dd, J=8.2, 6.2 Hz, 2H), 4.76-4.68 (t, J=6.3 Hz, 2H), 4.48-4.35 (m, 1H), 4.28-4.13 (dd, J=20.9, 11.0 Hz, 2H), 3.06-2.88 (ddd, J=19.7, 14.7, 7.1 Hz, 2H), 2.87-2.73 (m, 2H), 2.60-2.53 (m, 1H), 2.39-2.31 (d, J=7.7 Hz, 1H), 1.09-0.99 (dd, J=14.9, 6.2 Hz, 3H); MS (ESI) m/z: 428.2 [M+H]+

المصدر