تفاعل #85919

معادلة التفاعل

NaOH

HBr

NaNO2

1-(4-aminophenyl)piperidin-4-ol

HBr

→

pale brown solid

1-(4-bromophenyl)piperidin-4-ol

المذيبات

water

ظروف التفاعل

المعالجة

1. 1
   أخرىreacted at 100° C. for 3 hours
2. 2
   استخلاصextracted by EA
3. 3
   غسيلwashed by 2M NaOH
4. 4
   تجفيفdried over Na2SO4
5. 5
   تركيزconcentrated
6. 6
   أخرىpurified by flash chromatography

الإجراء التجريبي

1-(4-aminophenyl)piperidin-4-ol (600 mg, 3.12 mmol), HBr (14 mL, 48%), was mixed and cooled to 0° C., the solution of NaNO2 (215 mg, 3.12 mmol) in 2.3 mL water was added in. the mixture was stirred for 15 minutes, the solution of CuBr (246 mg, 1.72 mmol) in HBr (4.4 mL 4.8%) was added and reacted at 100° C. for 3 hours. 2M NaOH solution was added, extracted by EA, washed by 2M NaOH, dried over Na2SO4, concentrated and purified by flash chromatography. (PE:EA=3:1) to give 520 mg pale brown solid.

المصدر