تفاعل #85903

معادلة التفاعل

methyl 3-aminopropanoate hydrochloride

Et3N

5,7-dichloropyrido[4,3-b]pyrazine

→

title compound

methyl 3-(7-chloropyrido[4,3-b]pyrazin-5-ylamino)propanoate

المذيبات

THF

ظروف التفاعل

المعالجة

1. 1
   أخرىVolatiles were removed under reduced pressure
2. 2
   workup.ADDITIONthe residue was treated with water
3. 3
   استخلاصextracted with EtOAc
4. 4
   تجفيفThe combined extracts were dried over Na2SO4
5. 5
   ترشيحfiltered
6. 6
   تركيزconcentrated
7. 7
   أخرىThe residue was purified by chromatography

الإجراء التجريبي

A solution of methyl 3-aminopropanoate hydrochloride (4.88 mmol), Et3N (6.50 mmol) and 5,7-dichloropyrido[4,3-b]pyrazine (3.25 mmol) in THF (10 mL) was stirred at room temperature overnight. Volatiles were removed under reduced pressure, and the residue was treated with water and extracted with EtOAc. The combined extracts were dried over Na2SO4, filtered, and concentrated. The residue was purified by chromatography to afford the title compound. MS (m/z): 267 (M+H)+.

المصدر