تفاعل #85850

معادلة التفاعل

water

1-fluoro-4-nitrobenzene

methyl piperidine-4-carboxylate

K2CO3

→

methyl 1-(4-nitrophenyl)piperidine-4-carboxylate

المردود 58.6%

المذيبات

ACN

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةat reflux overnight
2. 2
   استخلاصextracted with EA
3. 3
   تجفيفdried over Na2SO4
4. 4
   أخرىThe volatiles were removed in vacuo
5. 5
   أخرىthe residue was purified by chromatography with PE/EA (10:1˜2:1)

الإجراء التجريبي

A solution of 1-fluoro-4-nitrobenzene (3.5 g, 24.81 mmol), methyl piperidine-4-carboxylate (4.26 g, 29.77 mmol) and K2CO3 in 40 mL of ACN, was stirred at reflux overnight. The mixture was added to 150 mL of water, extracted with EA, dried over Na2SO4. The volatiles were removed in vacuo, and the residue was purified by chromatography with PE/EA (10:1˜2:1) to give 3.84 g of methyl 1-(4-nitrophenyl)piperidine-4-carboxylate.

المصدر