تفاعل #85806

معادلة التفاعل

MeOH

Triisopropyl borate

5-bromo-N,N-dimethylpyridin-2-amine

n-BuLi

→

title compound

6-(dimethylamino)pyridin-3-ylboronic acid

المذيبات

THF

ظروف التفاعل

المعالجة

1. 1
   workup.ADDITIONAfter the completion of the addition
2. 2
   درجة الحرارةslowly warmed up
3. 3
   workup.STIRRINGstirred at the ambient temperature overnight
4. 4
   أخرىthe volatiles were removed under reduced pressure

الإجراء التجريبي

A solution of 5-bromo-N,N-dimethylpyridin-2-amine (500 mg, 2.5 mmol) in THF (10 mL) was treated with n-BuLi (1.2 mL, 3 mmol) at −72° C. for 2 hours. Triisopropyl borate (705 mg, 3.75 mmol) was then added dropwise. After the completion of the addition, the mixture was stirred at −72° C. for an additional 1 hour and slowly warmed up and stirred at the ambient temperature overnight. MeOH was carefully added, and the volatiles were removed under reduced pressure to give the title compound. MS (m/z): 167 (M+H)+.

المصدر