تفاعل #85558

معادلة التفاعل

benzothiazol-2-yl-(dihydrofuran-2-ylidene)-acetonitrile

hydrazine hydrate

→

title compound

المردود 67.0%

3-(5-Amino-4-benzothiazol-2-yl-2H-pyrazol-3-yl)-propan-1-ol

المردود 67.0%

المذيبات

ethanol

ظروف التفاعل

المعالجة

1. 1
   أخرىThe solvent was evaporated
2. 2
   أخرىthe resulting residue was triturated with dichloromethane
3. 3
   أخرىThe solid was isolated by filtration
4. 4
   غسيلwas then washed with dichloromethane and methanol

الإجراء التجريبي

The benzothiazol-2-yl-(dihydrofuran-2-ylidene)-acetonitrile (90 mg, 0.37 mmol) prepared above and hydrazine hydrate (25 mg, 0.5 mmol) were refluxed in ethanol (15 mL) for 10 hours. The solvent was evaporated and the resulting residue was triturated with dichloromethane. The solid was isolated by filtration and was then washed with dichloromethane and methanol to yield 60 mg (67%) of the title compound as a cream coloured solid. MS (m/z, ES+): 275.1 (M+1, 100). 1H NMR (300 MHz, ppm, DMSO-d6): δ (ppm), 11.5-12.2 (br s, 1H), 8.00 (d, 1H), 7.86 (d, 1H), 7.77 (t, 2H), 7.29 (t, 1H), 7.00-5.20 (br m, 2H), 4.55 (s, 1H), 3.52 (q, 2H), 2.83 (br s, 2H), 1.84 (q, 2H).

المصدر