تفاعل #85515

معادلة التفاعل

Ammonium hydroxide

2-aminobenzenethiol

3-aminopyrazole-4-carbonitrile

→

title compound

المردود 40.5%

4-Benzothiazol-2-yl-1H-pyrazol-3-ylamine

المردود 40.5%

المذيبات

ظروف التفاعل

المعالجة

1. 1
   أخرىThe resulting yellow solid was isolated by filtration
2. 2
   غسيلwashed with cold water

الإجراء التجريبي

A mixture of 2-aminobenzenethiol (100 mg, 0.8 mmol) and 3-aminopyrazole-4-carbonitrile (86 mg, 0.8 mmol) in 3 g of polyphosphoric acid was heated at 200° C. for 3 hours. The mixture was then poured into ice water and was neutralized with conc. Ammonium hydroxide solution. The resulting yellow solid was isolated by filtration and washed with cold water to yield the title compound (70 mg, 40%). MS (m/z, ES+): 217 (M+1, 100%); 1H NMR (300 MHz, ppm, DMSO-d6): δ 7.97 (d, 3J=7.8 Hz, 1H), 7.88 (s, 1H), 7.84 (d, 3J=8.0 Hz, 1H), 7.42 (m, 1H), 7.29 (m, 1H), 6.3 (br s, 2H).

المصدر