تفاعل #85446

معادلة التفاعل

Compound 509-A

{2-[Benzenesulfonyl-(4-fluoro-3-trifluoromethyl-benzyl)-amino]-benzo[b]thiophen-3-yl}-carbamic acid t-butyl ester

→

compound 509-B

المردود 78.6%

N-(3-Amino-benzo[b]thiophen-2-yl)-N-(4-fluoro-3-trifluoromethyl-benzyl)-benzenesulfonamide

المردود 78.6%

المذيبات

HCl

dioxane

diethyl ether

ظروف التفاعل

المعالجة

1. 1
   ترشيحfiltered
2. 2
   غسيلwashed with diethyl ether
3. 3
   أخرىdried under vacuo

الإجراء التجريبي

Compound 509-A (1.0 g, 1.72 mmol) was dissolved in 4N HCl in dioxane (20 mL) and stirred at ambient temperature for 18 h. The resultant suspension was diluted with diethyl ether, filtered, washed with diethyl ether and dried under vacuo to afford 0.65 g of compound 509-B. MS: m/z 481.0 (MH+).

المصدر