تفاعل #85267

ord-9f4899af8c4b4835b201c86493f8bd90

معادلة التفاعل

CC(C(=O)Nc1ccc(C(=O)O)c(C(C)(C)C)c1)n1cc(C#N)c(-c2cc(Cl)ccc2C2CC2)cc1=O
tert-butyl 4-({2-[4-(5-chloro-2-cyclopropylphenyl)-5-cyano-2-oxopyridin-1(2H)-yl]propanoyl}amino)benzoic acid
O=C(O)C(F)(F)F
TFA
→
CC(C(=O)Nc1ccc(C(=O)O)cc1)n1cc(C#N)c(-c2cc(Cl)ccc2C2CC2)cc1=O
4-({2-[4-(5-Chloro-2-cyclopropylphenyl)-5-cyano-2-oxopyridin-1(2H)-yl]propanoyl}amino)benzoic acid

المتفاعلات

CC(C(=O)Nc1ccc(C(=O)O)c(C(C)(C)C)c1)n1cc(C#N)c(-c2cc(Cl)ccc2C2CC2)cc1=O
tert-butyl 4-({2-[4-(5-chloro-2-cyclopropylphenyl)-5-cyano-2-oxopyridin-1(2H)-yl]propanoyl}amino)benzoic acid
O=C(O)C(F)(F)F
TFA

الكواشف

لا شيء

ظروف التفاعل

الظروف التفصيلية
See reaction.notes.procedure_details.

الإجراء التجريبي

66 mg (0.13 mmol) of tert-butyl 4-({2-[4-(5-chloro-2-cyclopropylphenyl)-5-cyano-2-oxopyridin-1(2H)-yl]propanoyl}amino)benzoic acid (racemate) (Example 18.3A) were hydrolysed with TFA according to General Method 2. Yield: 39 mg (68% of theory)

المصدر

DOI: 10.6084/m9.figshare.5104873.v1براءة الاختراع: US09434690B2uspto-grants-2016_09