تفاعل #8516

معادلة التفاعل

Phosphoryl chloride

N′-(2,6-dichloro-4-trifluoromethylphenyl)-chloroacetohydrazide

→

title compound

المردود 90.0%

N′-(2,6-dichloro-4-trifluoromethylphenyl)-chloroacetohydrazonoyl chloride

المردود 90.0%

المذيبات

toluene

ظروف التفاعل

المعالجة

1. 1
   أخرىThe cooled mixture was evaporated
2. 2
   استخلاصthe residue extracted with cyclohexane
3. 3
   أخرىevaporated

الإجراء التجريبي

Phosphoryl chloride (500 microlitres, 1.7 equivalents) was added in one portion to a stirred solution of N′-(2,6-dichloro-4-trifluoromethylphenyl)-chloroacetohydrazide (1.0 g, 3.11 mmol) in toluene (20 ml) and heated at 70° C. under an argon atmosphere for 20 hours. The cooled mixture was evaporated and the residue extracted with cyclohexane. The extracts were combined and evaporated to give the title compound (0.971 g) as an orange oil, NMR 4.4 (s, 2H), 7.55 (s, 2H), 7.7 (s, 1H). The yield was 90%.

المصدر