تفاعل #8505

معادلة التفاعل

sodium hydroxide

2-butene-1,4-diol

benzyl chloride

→

( 18 )

المردود 114.5%

1,4-Dibenzyloxy-2-butene

المردود 114.5%

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةThe reaction mixture was cooled down
2. 2
   أخرىseparated
3. 3
   workup.ADDITIONafter the addition of water (90 ml)
4. 4
   workup.ADDITIONTo the organic layer was added sulfuric acidic brine
5. 5
   أخرىseparated
6. 6
   workup.ADDITIONmixed with ethyl acetate
7. 7
   تركيزconcentrated under reduced pressure

الإجراء التجريبي

To 48% aqueous sodium hydroxide (127.8 g) was added tetra-n-butylammonium bromide (3.3 g, 10 mmol). The mixture was heated to 60° C. To the mixture was added 2-butene-1,4-diol (17) (30.0 g, 340 mmol), to which was added dropwise benzyl chloride (94.8 g, 743 mmol) at 80±15° C. The mixture was stirred at the same temperature for 2 hours. The reaction mixture was cooled down, and separated after the addition of water (90 ml). To the organic layer was added sulfuric acidic brine. The solution was neutralized by aqueous sodium hydrogen carbonate, separated, mixed with ethyl acetate and concentrated under reduced pressure to yield the objective (18) (104.5 g, quantitative) as an oil residue.

المصدر