تفاعل #84912

معادلة التفاعل

2-[4-(5-chloro-2-cyanophenyl)-2-oxopyridin-1(2H)-yl]propanoic acid

methyl 4-amino-2-methylbenzoate

→

Methyl 4-({2-[4-(5-chloro-2-cyanophenyl)-2-oxopyridin-1(2H)-yl]propanoyl}amino)-2-methylbenzoate

ظروف التفاعل

المعالجة

1. 1
   أخرىFollowing aqueous work-up, the desired product was precipitated
2. 2
   workup.ADDITIONa mixture of a little water, acetonitrile and DMF

الإجراء التجريبي

120 mg (0.39 mmol) of 2-[4-(5-chloro-2-cyanophenyl)-2-oxopyridin-1(2H)-yl]propanoic acid (racemate) and 1.1 eq. of methyl 4-amino-2-methylbenzoate were reacted according to General Method 5A. Following aqueous work-up, the desired product was precipitated using a mixture of a little water, acetonitrile and DMF. Yield: 120 mg (69% of theory)

المصدر