تفاعل #84887

معادلة التفاعل

tert-butyl 2-(2-fluoro-4-nitrobenzoyl)-2-methylhydrazinecarboxylate

→

2-Fluoro-N-methyl-4-nitrobenzohydrazide

المذيبات

hydrochloric acid dioxane

ظروف التفاعل

المعالجة

1. 1
   تركيزThe reaction mixture was concentrated under reduced pressure
2. 2
   غسيلwashed with saturated aqueous sodium bicarbonate solution
3. 3
   تجفيفThe organic phase was dried (sodium sulphate)
4. 4
   ترشيحfiltered
5. 5
   تركيزconcentrated under reduced pressure

الإجراء التجريبي

A solution of 3.6 g (11.5 mmol) of tert-butyl 2-(2-fluoro-4-nitrobenzoyl)-2-methylhydrazinecarboxylate in 57 ml of 4-molar hydrochloric acid/dioxane solution was stirred at RT for 3 h. The reaction mixture was concentrated under reduced pressure and the residue was taken up in ethyl acetate and washed with saturated aqueous sodium bicarbonate solution. The organic phase was dried (sodium sulphate), filtered and concentrated under reduced pressure. Yield: 2.0 g (81% of theory)

المصدر