تفاعل #84759

معادلة التفاعل

(2-amino-4-methoxyphenyl)methanol

→

title compound

المردود 35.3%

2-amino-4-methoxybenzaldehyde

المردود 35.3%

المذيبات

dichloromethane

ظروف التفاعل

المعالجة

1. 1
   ترشيحThe solid was filtered off
2. 2
   تركيزthe filtrate was concentrated
3. 3
   أخرىThe residue was purified by silica gel chromatography (petroleum ether:ethyl acetate=6:1)

الإجراء التجريبي

A mixture of (2-amino-4-methoxyphenyl)methanol (20 g, 131.0 mmol) and manganese oxide (68 g, 786.0 mmol) in dichloromethane (300 mL) was stirred at room temperature overnight. The solid was filtered off, and the filtrate was concentrated. The residue was purified by silica gel chromatography (petroleum ether:ethyl acetate=6:1) to give the title compound (7 g, 35%) as a yellow solid. MS (ES+) C8H9NO2 requires: 151, found: 152 [M+H]+.

المصدر