تفاعل #84748

معادلة التفاعل

(2-amino-5-bromo-3-fluorophenyl)methanol

→

title compound

المردود 85.0%

2-amino-5-bromo-3-fluorobenzaldehyde

المردود 85.0%

المذيبات

dichloromethane

ظروف التفاعل

المعالجة

1. 1
   ترشيحThe solid was filtered off
2. 2
   تركيزthe filtrate was concentrated

الإجراء التجريبي

A mixture of (2-amino-5-bromo-3-fluorophenyl)methanol (13 g, 59.4 mmol) and manganese oxide (31 g, 356.4 mmol) in dichloromethane (400 mL) was stirred at room temperature overnight. The solid was filtered off, and the filtrate was concentrated to give the title compound (11 g, 85%) as a light yellow solid, which was directly used in the next step without further purification.

المصدر