تفاعل #8467

معادلة التفاعل

product

alpha-bromo-3′-methoxy-4′-chloropropoxyacetophenone

2-amino-4-picoline

→

title compound

المردود 70.5%

2-(4′-chloropropoxy-3′-methoxyphenyl)-7-methylimidazo[1,2-a]pyridine hydrobromide

المردود 70.5%

المذيبات

ethanol

ظروف التفاعل

المعالجة

1. 1
   أخرىevaporated to a yellow solid
2. 2
   ترشيحThe mixture was filtered
3. 3
   أخرىthe solid product collected

الإجراء التجريبي

A solution of the product of Step B (1.44 g) and 2-amino-4-picoline (0.486 g) in ethanol (6 mL) was heated at 73° C. for 1 hour. The reaction mixture was cooled to ambient temperature and evaporated to a yellow solid. The solid was stirred with 25 mL of dichloromethane for approximately 10 minutes. The mixture was filtered and the solid product collected to yield the title compound (1.3 g).

المصدر