تفاعل #8465

معادلة التفاعل

product

alpha-bromo-2′-methyl-4′-chloropropoxyacetophenone

2-amino-4-picoline

→

2-(4′-chloropropoxy-2′-methylphenyl)-7-methylimidazo[1,2-a]pyridine

المذيبات

ethanol

methanol dichloromethane

ظروف التفاعل

المعالجة

1. 1
   أخرىThe resin was removed via filtration
2. 2
   أخرىthe filtrate evaporated
3. 3
   أخرىThe title compound was precipitated from ethyl acetate upon addition of hexanes
4. 4
   أخرىused without further purification

الإجراء التجريبي

A solution of the product of Step B (6.77 g) and 2-amino-4-picoline (2.4 g) in ethanol (22 mL) was heated at 72° C. for 10 hours. The reaction mixture was cooled to ambient temperature and dissolved in methanol/dichloromethane and treated with Dowex® 550A basic resin until the pH of the mixture was 7. The resin was removed via filtration and the filtrate evaporated. The title compound was precipitated from ethyl acetate upon addition of hexanes and used without further purification.

المصدر