تفاعل #84552

معادلة التفاعل

water

3-fluorophenol

ethyl 2-bromo-2-methylpropanoate

K2CO3

→

title compound

المردود 47.1%

ethyl 2-(3-fluorophenoxy)-2-methylpropanoate

المردود 47.1%

المذيبات

acetone

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةwas refluxed overnight
2. 2
   استخلاصThe resulting mixture was extracted with DCM (40 mL×2)
3. 3
   غسيلThe combined organic phases were washed with brine (40 mL×2)
4. 4
   تجفيفdried over anhydrous Na2SO4
5. 5
   تركيزconcentrated in vacuo
6. 6
   أخرىThe residue was purified by a silica gel column chromatography (PE/EtOAc (V/V)=4:1)

الإجراء التجريبي

A mixture of 3-fluorophenol (3.36 g, 30.0 mmol), ethyl 2-bromo-2-methylpropanoate (8.78 g, 45.0 mmol) and K2CO3 (6.22 g, 45.0 mmol) in acetone (50 mL) was refluxed overnight. The mixture was cooled to rt and 60 mL of water was added. The resulting mixture was extracted with DCM (40 mL×2). The combined organic phases were washed with brine (40 mL×2), dried over anhydrous Na2SO4 and concentrated in vacuo. The residue was purified by a silica gel column chromatography (PE/EtOAc (V/V)=4:1) to give the title compound as colorless liquid (3.20 g, 47%).

المصدر